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by bione at 05-04-2020, 07:36 PM
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by debatical at 03-16-2020, 12:24 PM
I'm approaching this from a software perspective, and this might pertain to anyone had experience with TensorFlow and similar libraries for machine learning and neural nets.

My question is this: in order for artificial intelligence to more accurately simulate consciousness, bodily processes that may influence thoughts, and more complex response to stimuli that may not always be deterministic, would a new library similar to TensorFlow or PyTorch be necessary, or are these libraries sufficient enough? I'm pretty sure you could implement neural networks with <i>some</i> stochastic input/output with a software like TensorFlow, see this paper:<!--StartFragment--><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936290/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936290/</a><!--EndFragment-->

But I'm wondering if a <b>new</b> software library, potentially predicated on <b>new</b> maths like Linear-Time Logic/Fuzzy Logic, would be more useful to those in the biotech world (which touches upon neuroscience, biochemistry, even philosophy). Are natural processes of the body, both internal and external, sometimes non-deterministic or act in a way that could potentially be simulated by a slight amount of randomness (or a threshold of randomness before a state like hunger is switched on?)
by Iapetus at 03-10-2020, 07:17 PM
Greetings,

I hope this is the correct sub-forum!

There has been some controversy as to whether the four 3-6 amino acid residue sequence additions found in the spike protein of 2019-nCoV could be of potential significance. Some had argued all four matching samples of HIV-1 was of interest, while others have suggested the comparatively short sequences and presence of sequence gaps potentially matching hundreds of other candidates (though not necessarily all four as with HIV-1), made it less helpful for identifying a possible intermediate carrier.

The main study which originally identified these additions has been hotly debated in its wording and conclusions and is currently withdrawn for review by its authors, however the presence of these sequences and their persistence has not been challenged: https://www.biorxiv.org/content/10.1101/...1.full.pdf

Taking these findings in a different direction, I wanted to clarify whether it would be theoretically possible for these four potential HIV-1 matches to inherit larger HIV-1 spike components from a co-infection of HIV-1 and 2019-nCoV within a single human host cell via recombination, using these fragments as a translation template?

I imagine it would depend on modeling whether the location and spacing of these four template markers could potentially match an equivalent range in a candidate HIV-1 sequence that, if transferred by recombination, could constitute any significant change in functional capacity of the 2019-nCoV receptor site (where these 4 markers are located).

Obviously the main concern being whether the ability to infect HIV-1 target receptors could be inherited through such a hypothetical transfer.

Please bear in mine I have no real world experience in molecular biology or genetics as my background is Computer Science and IT.

Are there any know analogs for such a recombination naturally of material from one viral source to another with large sequence gaps? If so I was mainly interested in probability for and against such a scenario occurring given the present expression of these four candidate sequence markers and their locations.

As a possible mechanism for co-infection, I considered a hypothetical scenario where an individual previously infected with HIV-1 subsequently contracted 2019-nCoV. During the later disease progression, the patient develops hemoptysis.

Could there be a possible mechanism whereby HIV-1 infected blood in the airways could transfer HIV-1 into a 2019-nCoV infected cell?

Is there any other mechanism whereby a person infected with both diseases might see them co-infect the same cell and transfer material, despite the fact they target different receptors, possibly through some Gag particle assembly mechanism or other known process?

While many have been quick to dismiss the likelihood of 2019-nCoV inheriting parts of HIV-1, they also point out it is not altogether impossible. This is the part I am unclear on. They largely base their conclusions on the assumption of a scenario where the material is inherited from an intermediary animal, while indicating more research is needed to determine if that is indeed the case, as such a candidate animal has yet to be found.

It seems remarkable that these four additions or 'inserts' (debate exists on the classification) appear to be conserved in all available 2019-nCoV sequences. It COULD tend to reinforce an artificial origin, in a hypothetical scenario where such recombination was theoretically possible yet necessitated long term stability of the template to facilitate what may require very rare circumstances (the probability equation) and many random recombinations to achieve.

Admittedly the scenario seems unlikely. It also may be that I am simply ignorant to the reasons why both virus entering the same cell and recombining in such a way is not actually possible. However, I felt compelled to ask.

Best regards,

-James
by protechrec at 02-11-2020, 10:12 PM
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by Teamway at 01-30-2020, 05:45 PM
<p>Hello everyone</p><p>I am working on Whole Genome BSA re-sequencing.. and found variations between resistant and susceptible bulks and narrowed down to variation in 30 kb region on&nbsp;one chromosome. Now I want to develop overlapping primers for the specific region.. Can anyone please describe&nbsp;me the procedure for developing the same&nbsp;....</p><p>Thank you&nbsp;</p>
by Serbin231 at 01-08-2020, 08:54 AM
Is there any user friendly way to find rare mutations in the individual human whole genome sequencing raw data? (from Dante, 30x coverage).

To be more specific, I want to find mutations from this paper: https://docs.google.com/document/d/1EkRM...sp=sharing (it's very short, less than one page).

But I'm confused. In their paper they just talk about genes (RAD21, B3GAT2, SMC3, SCN11A , SCN5A, SCN9A, SCN10A, SCN11A, TRPA1), but not mutations? Can we find thats diseased-mutations which they talking about in genes, which their list? Or is there not enough data in the paper/study for this?

And if there is not enough data, which data I need to request from authors?

Or those genes have kind a "gold standard sequences" and if that sequence different from standard - there is "diseased" gene? (I have only very basic genetics and bioinformatics knowledges)
by CHANDA7 at 09-16-2019, 12:54 AM
can anyone help me by defining what is "minimal promoter" and "basal promoter"? what are the elements they consist of? what are the basic difference between the two
by nraj at 07-27-2019, 01:36 AM
Hi All,

I recently started working in a biotech incubator offering space and equipment to about 5 start ups.I just wanted to cross reference some info I have been given. Can someone please offer me a rundown of the most commonly used biotech lab equipment necessary for an ordinary start up. And can you please segment that list in this way.

1) Lab Equipment that can be shared between companies

2) Lab Equipment that cannot be shared between companies

3) Lab Equipment that isn't completely necessary, but would be helpful to have in a lab space.

I hope you all can help me out. Thanks!
by priyansha sinha at 07-11-2019, 06:29 AM
Dear sir,

I've completed my B.Tech degree in biotechnology this year and qualified GATE as well. Since I've not taken admission in any college, I am looking to work as an intern in some company or to do a project in R&D department (Biotech) in any institute. I kindly request you to help me and let me know if there's any such opportunity available in India (specifically Bangalore) that I could pursue.

Thank you
Priyansha
by YashulBhardwaj at 07-10-2019, 08:09 AM
I Yashul Bhardwaj from haryana, i recently qualify the JNU-CEEB 2019 for M.tech Biotech with rank of 15.
It is basically a DBT Sponsored Program with the fellowship equivalent to GATE.
After seat allotment, i got allotment at West Bengal University of Technology (Kolkata).

My Request is that, is this alloted university is good enough to pursue the M.tech as the N.I.Ts are in terms of the hands on training and placement ?? Because I am not getting much info about this from net surfing.

Kindly suggest me, should I go for M.tech in this university or not??  ... as the seat blocking procedure is about to begin from 11th to 14th July.
Kindly response on this as soon as possible.
by natarajan at 06-07-2019, 03:39 AM
I would like to know the compiled list of all branches of Mtech / MS  offered by the IITs and other premier institutes in India for which one can apply through valid score in GATE biotechnology etc. I want to know this to get an idea of what other branches one can apply for in addition to biological sciences with a valid score in GATE BT. Kindly let me know.Thanking in advance.
by SuperLabTech at 05-11-2019, 01:48 AM
[Image: source.gif]

29-year-old lab technician from New Jersey, USA. I have been meaning to join a forum like this about biotechnology. I'm looking forward to checking the place out.
by Levi4than at 03-04-2019, 08:30 AM
Is it possible to embed transmembrane domain to the protein by inserting sequence which codes mentioned domain to gene that codes the enzyme, in the way that it would allow the protein to become an IMP (integral membrane protein) without depriving it of its enzymatic properties?

I would really appreciate a helpful answer.
by Sushmitha at 02-27-2019, 04:01 AM
Can anybody please suggest me some good seminar topics for biotechnology engineering

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by Camomile at 02-20-2019, 05:31 AM
Hi Everyone!
I am really pleased to join your community. I find it really enriching and useful.

Today I am writing to you with a really broad question regarding background referred to analytical chemistry.
Currently, I am writing my Master thesis and due to the fact that am only an engineer of biotech; some from aspects of pure analytical chemistry is really not understandable.

Honestly, I am left without an advisor and have nobody to ask for help.
Lets move to the point; I am ordering my results and found myself in a position where I do not understand the difference in the application of cyclic voltammetry and square wave voltammetry.

I made few measurements of a suspension containing an enzyme and a buffer ( not activity one ). I hold in a hand a publication where research group applied a square wave voltammetry and as a standardized value; applied a specific pick on exact potential. I will be really grateful for receiving a short explanation about the difference between those two techniques.
by Gunaseelan at 11-26-2018, 03:31 PM
Hello, everyone.i am gunaseelan ,2nd year btech biotech student.here many professionals guides biotech students .I am really happy to join this community.thanks everyone...

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by NikitaM at 11-03-2018, 11:13 PM
Hello dude,

Good evening to all. I'm a newbie here. I would like to introduce myself with all of you guys. I hope everyone here is doing well so far.

Thank you so much!
by sj26 at 10-24-2018, 04:30 AM
Hello
From where i can learn perl programming for bioinformatics??
by SACHIN THOMAS at 10-03-2018, 05:33 AM
Hello all,
I'm a student doing my bachelor's in Biotechnology Engineering.
Hope I can contribute and learn more from this platform.
Thank You
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