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CANCP: new 50-Gene Cancer Panel Test launched by Mayo Clinic
A new 50-gene cancer panel test launched by the Mayo Clinic is designed to generate “results that oncologists can use to help find the right drug the first time.” That’s according to Dr Benjamin Kipp, a Mayo Clinic molecular geneticist and lead designer of the test. The new test is called CANCP, an abbreviation for Solid Tumor Targeted Cancer Gene Panel by Next-Generation Sequencing.

CANCP is designed to scan ‘hot spots’ of the 50 genes, meaning specific regions of the genes that are known to frequently harbour tumour-causing mutations. Mutations in these 50 genes have been identified as contributing to tumour growth and resistance to chemotherapy. It is specific to solid tumours. The test is aimed at providing a treatment regime tailored to the individual patient. Dr Axel Grothey, a Mayo Clinic oncologist who orders CANCP on selected tumours explains the utility of the test in individualising treatment: “Every patient’s cancer is different, and oncology is moving away from treating cancer based on its location in the body in favour of selecting the best medication for the individual patient based on molecular changes in the tumour….This test helps providers identify such molecular changes without infusing irrelevant details from genes that we know will not affect our choice of medications.”

Currently, CANCP is available to both Mayo Clinic patients and to providers worldwide via Mayo Medical Laboratories. Testing is conducted in the Clinical Laboratory Improvement Amendments (CLIA) -certified Next-Generation Sequencing Lab of the Mayo Clinic Department of Laboratory Medicine and Pathology (DLMP). DLMP and Mayo Medical Laboratories also offer another 17-gene next-generation sequencing panel screening test for hereditary colorectal cancers. Both these tests were developed together with the Mayo Clinic Center for Individualized Medicine.


Press release: Mayo Clinic; available at [Accessed 1 May 2014].
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