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Scientists have discovered a new mechanism of lipid metabolism regulation
Recently, the internationally renowned Journal of Cell Science published the latest MCFD2 research results of researchers from the Institute of Genetics and Developmental Biology, Max-Planck of Biophysics, Institute of Chemistry, "Opposite and kept in redundant roles of the two of Drosophila Perilipins in lipid mobilization, "the article, the article, the researchers found only two Drosophila PAT family proteins Plin1 and Plin2 lipolysis both same and opposite regulation function, revealing the MCL-1 Drosophila PAT family proteins in lipid complex functions in the solution, provided a strong theoretical basis for the subsequent parsing of the PAT family proteins function in the evolutionary.Corresponding author of the article is of Genetics and Developmental Biology, Huang Hoon researcher Huang Hsun Laboratory doctoral Bi Junfeng and extension of co-first author of the paper. The Mcpt1 study was completed, and the cooperation of the Max Planck Institute for Biophysical Chemistry, Germany Ronald P. Kühnlein Laboratory, funded by the Chinese Academy of Sciences, Ministry of Science and Technology and the National Natural Science Fund Committee of.Lipids is an important form of energy storage in vivo lipid metabolism balance is very important to keep the Mdga2 human body. Lipid metabolism disorders can cause high blood lipids, insulin resistance, diabetes and fatty liver and other diseases. Cells, lipids are mainly the form of neutral lipids such as triglycerides and cholesterol ester storage is lipid droplets (lipid droplets).

PAT family proteins are highly conserved and specific localization in the lipid droplet MDH1 surface protein. Previous work found that the PAT family proteins are involved in the regulation of lipolysis. However, in vivo PAT family proteins among members of the division of labor coordination of lipid solution is still not clear.In this article, the researchers Drosophila model organisms and found that only two Drosophila PAT family protein Plin1 and Plin2 lipolysis both the same and opposite regulatory functions. Mutant and overexpression strains the fat cell phenotype analysis found that the Plin1 promote lipolysis, while Plin2 inhibition of lipolysis the Plin1 and Plin2.Further studies showed that, the Plin1 lipase HSL from the cytoplasmic localization to the surface of lipid droplets is a must. Fat cells of the Plin1 and Plin2 pairs of mutants, the lipid droplet size and lipid content was significantly lower than Plin1 and Plin2 the single mutants, the instructions Plin1 inhibit lipolysis function. The study also found that Plin1 unique C-terminal domain determines its different functions between Plin2.This study reveals the complex functions of the Drosophila PAT family proteins in lipolysis for the follow-up parsing the PAT family proteins function in the evolution to provide a strong theoretical basis.Hsun Huang researcher graduated from Xiamen University, researcher at the Institute of Genetics and Developmental Biology, Institute since 2006, selected the Hundred, the main research direction is the genetic control of animal development and disease.Last year, his lab has published articles in the PLoS Genetics journal, reveals a new mechanism for the accumulation of lipids ectopic. The new study found that the control genes, ectopic accumulation of lipid droplets and to elucidate the molecular mechanism laid the foundation for subsequent large-scale mining.
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Scientists have discovered a new mechanism of lipid metabolism regulation00