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Potential lethality of three types of antibiotics can damage cellular DNA
Internationally renowned magazine "Science" in Science published the latest HSP26 research results from the Massachusetts Institute of Technology and Boston University researchers "Oxidation of the Guanine Nucleotide the Pool Underlies Cell Death by Bactericidal Antibiotics", the article, the researchers have opened a The three main types of antibiotics potentially killing mechanisms: drug generated a number of destructive molecules through a series of cellular events that caused the HSP90AA1 fatal damage to cellular DNA.Penicillin and other antibiotics pharmaceutical revolutionary change once fatal disease into in order to easily curable diseases. However, despite the antibiotics in clinical practice for more than 70 years, its exact mechanism of killing bacteria is still a mystery to be solved.The researchers said that a detailed understanding of this mechanism could help scientists HSP90AB1 improve existing drugs. In the past 40 years, only a few new antibiotics are developed, while a large number of bacterial strains but then the currently available drug tolerance.James Collins, professor of biomedical engineering at Boston University, said: "This may enhance the killing effect of our current 'arsenal' to reduce the required dose, or the bacterial strain is sensitive to existing antibiotics to.

In 2007, Collins proved that the three HSP90B1main types of antibiotics - quinolones, beta-lactams and aminoglycosides - can be to generate highly destructive hydroxyl free radicals, molecules methoxycinnamate (OMC) radicals, the destruction of bacterial cells. At that time, he and other researchers speculated that free radicals launched a comprehensive attack on all cellular components they encounter.MIT biology professor Graham Walker said: "They are almost all produced HSPA13 responses. They chase lipid, the oxidation of protein, they can oxidize DNA." However, in the new study, researchers found that this damage part is not lethal,The researchers demonstrated that the fatal injury can be caused by bacteria is the guanine damage induced by hydroxyl, guanine (G) is the four basic building blocks of DNA nucleotide one. When this damage guanine inserted into the DNA, the bacteria will endeavor to repair this damage, but eventually accelerate the death. "This is not the cause of all the killing effects of reasons, but the fact that it occupies a very important proportion of," Walker said.Initially, Walker for the study of DNA repair enzymes so that the researchers suspect that this oxidized guanine may play a role in the antibiotic-mediated cell death. In the first study phase, they found a specific DNA polymerase DinB very good use of the oxidation of guanine components to synthesize DNA.That DinB is not only oxidation of guanine during DNA replication, however, inserted into the correct base opposite cytosine © will be inserted into the opposite adenine (A).The researchers found that when too much oxidation of guanine incorporation into the new strand of DNA, the cell will not be able to successfully remove these damage, thus leading to death.
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