08-26-2013, 06:10 PM
[b]Beware of the deadly infection by CRE species !![/b]
Of late some of the pathogens belonging to the Enterobacteriacea family have become immune to antibiotics especially the drug carbapenem which led to the development and prevalence of the deadly infection named as Carbapenem resistant Enterobacteriacea (CRE) infection.
The main pathogen behind CRE infection identified so far include Klebsiella pneumonia which has shown resistance to the antibiotic carbapenem. The severity of the infection can be well understood by the fact that the antibiotic Carbapenem is the last line of defence used against any bacterial infection and any bacteria which is immune to this antibiotic is considered deadly as there are no other available antibiotic to control the infection causing bacterium.
The mechanism of resistance towards antibiotics is developed by synthesis of some enzymes by the particular strain which inhibits the effect of Carbapenem thus becoming carbapenem resistant. Examples of such enzymes include Klebsiella pneumonia carbapenemase (KPC), New Delhi Metallo -beta lactamase (NDM), VIM and IMP.
CRE infection is mainly considered as hospital oriented infection where the patients who are on mechanical breathing supporter, patients with urinal catheter or IV catheter are the susceptible groups. As most of the Enterobacteriacea species habitats human gut and if they become the primary source of infection by proving its Carbapenem resistance there is always chance of this strain being entering blood stream and other parts of the body. The infectious strain entering the blood stream of the patient proves to be fatal.
Anyone can contract the CRE infection by being exposed to the infectant or by coming in contact with the infected patients feces and unhealed wounds. Once detected with CRE infection the patient must be isolated from the group and treated. The attending physicians should ensure their safety by adopting practices like use of sterile gloves, mask, over-coats and washing hands pre and post visits to the patient. Also the hospitals should ensure good hygienic practices and disinfection methods. The infected person should maintain a good hygiene and follow his/ hers health providers advice to overcome the situation.
The common ailments recorded as result of CRE infection include urinary tract infection, pneumonia, blood related infections and infections of the accidental or surgical wounds.
Tracking CRE infection at the earliest will enable the control of the infection. Also by maintaining the patient records (which should include the information on previous episode of hospitalization outside the country or medical service like surgery received outside the country) will help to track the infection.
Of now the evidence of CRE infection is recorded in United States and in some of the European and Asian countries.
The cleverer the humans are in developing drugs the more cleverest becomes the microbes causing challenges like life threatening CRE infections.
Of late some of the pathogens belonging to the Enterobacteriacea family have become immune to antibiotics especially the drug carbapenem which led to the development and prevalence of the deadly infection named as Carbapenem resistant Enterobacteriacea (CRE) infection.
The main pathogen behind CRE infection identified so far include Klebsiella pneumonia which has shown resistance to the antibiotic carbapenem. The severity of the infection can be well understood by the fact that the antibiotic Carbapenem is the last line of defence used against any bacterial infection and any bacteria which is immune to this antibiotic is considered deadly as there are no other available antibiotic to control the infection causing bacterium.
The mechanism of resistance towards antibiotics is developed by synthesis of some enzymes by the particular strain which inhibits the effect of Carbapenem thus becoming carbapenem resistant. Examples of such enzymes include Klebsiella pneumonia carbapenemase (KPC), New Delhi Metallo -beta lactamase (NDM), VIM and IMP.
CRE infection is mainly considered as hospital oriented infection where the patients who are on mechanical breathing supporter, patients with urinal catheter or IV catheter are the susceptible groups. As most of the Enterobacteriacea species habitats human gut and if they become the primary source of infection by proving its Carbapenem resistance there is always chance of this strain being entering blood stream and other parts of the body. The infectious strain entering the blood stream of the patient proves to be fatal.
Anyone can contract the CRE infection by being exposed to the infectant or by coming in contact with the infected patients feces and unhealed wounds. Once detected with CRE infection the patient must be isolated from the group and treated. The attending physicians should ensure their safety by adopting practices like use of sterile gloves, mask, over-coats and washing hands pre and post visits to the patient. Also the hospitals should ensure good hygienic practices and disinfection methods. The infected person should maintain a good hygiene and follow his/ hers health providers advice to overcome the situation.
The common ailments recorded as result of CRE infection include urinary tract infection, pneumonia, blood related infections and infections of the accidental or surgical wounds.
Tracking CRE infection at the earliest will enable the control of the infection. Also by maintaining the patient records (which should include the information on previous episode of hospitalization outside the country or medical service like surgery received outside the country) will help to track the infection.
Of now the evidence of CRE infection is recorded in United States and in some of the European and Asian countries.
The cleverer the humans are in developing drugs the more cleverest becomes the microbes causing challenges like life threatening CRE infections.
![[+]](https://www.biotechnologyforums.com/images/netpen-pro/collapse_collapsed.png)