12-16-2012, 12:17 AM
(This post was last modified: 12-16-2012, 12:42 AM by ExpertScie.)
“Many a times, Journey is more beautiful than destination”
Each step of development in medical science brings new hope and new life to millions and billions of patients, all around the world. One such developmental step is in the field of treatment of “Fragile x syndrome”. A new therapeutic strategy has been developed and is with lot of potential. This research was led by Dr. Lucia Ciranna at the University of Catania in Italy.
In this field, a decade back, it was observed that blocking mGluR5 gave promising results in the treatment of Fragile X syndrome. Blocking mGluR5 therefore has been identified as potential way to treat Fragile X syndrome and many drugs were tested for the same. One such drug known as fenobam was beneficial in adults with FXS.
But further, Ciranna and colleagues seems to have identified other potential mechanisms for FXS. In this they showed that blockade of serotonin 7 (5-HT7) receptor, like mGluR5 greatly reduces long term depression mediated by mGlu receptors. Depression in neuroscience is nothing but reduction in ability of nerve cells to communicate or decrease in neuronal synapses or in its effectiveness.
More importantly this effect was detected in one of the brain structure which is mostly involved in learning and memory, that is hippocampus.
This research and its results had given a new way in the therapy of Fragile X Syndrome. Thus now selective agonists for receptors 5-HT7 can be used as pharmacological and medical tool for treatment. This study further identified a new compound LP-211 which has high affinity as well as selectivity towards 5-HT7 receptors. This way the data showed that LP-211 act as agonist of 5-HT7 receptor.
Thus a potential new treatment for Fragile X syndrome is on its way, starting form mGluR5 up to LP-211 and its clinical trials!
I am not sure whether it is true for all that “Any journey is more beautiful than destination”
But, definitely I can say that for any researcher or scientist who dedicate his decades of life in finding a thing or a new molecule, it is true!
Each step of development in medical science brings new hope and new life to millions and billions of patients, all around the world. One such developmental step is in the field of treatment of “Fragile x syndrome”. A new therapeutic strategy has been developed and is with lot of potential. This research was led by Dr. Lucia Ciranna at the University of Catania in Italy.
In this field, a decade back, it was observed that blocking mGluR5 gave promising results in the treatment of Fragile X syndrome. Blocking mGluR5 therefore has been identified as potential way to treat Fragile X syndrome and many drugs were tested for the same. One such drug known as fenobam was beneficial in adults with FXS.
But further, Ciranna and colleagues seems to have identified other potential mechanisms for FXS. In this they showed that blockade of serotonin 7 (5-HT7) receptor, like mGluR5 greatly reduces long term depression mediated by mGlu receptors. Depression in neuroscience is nothing but reduction in ability of nerve cells to communicate or decrease in neuronal synapses or in its effectiveness.
More importantly this effect was detected in one of the brain structure which is mostly involved in learning and memory, that is hippocampus.
This research and its results had given a new way in the therapy of Fragile X Syndrome. Thus now selective agonists for receptors 5-HT7 can be used as pharmacological and medical tool for treatment. This study further identified a new compound LP-211 which has high affinity as well as selectivity towards 5-HT7 receptors. This way the data showed that LP-211 act as agonist of 5-HT7 receptor.
Thus a potential new treatment for Fragile X syndrome is on its way, starting form mGluR5 up to LP-211 and its clinical trials!
I am not sure whether it is true for all that “Any journey is more beautiful than destination”
But, definitely I can say that for any researcher or scientist who dedicate his decades of life in finding a thing or a new molecule, it is true!
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