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Question about bioreactor scale up
#1
Hi If anyone can help me answer the following questions below, it would be a great help. Its about bioreactors, turbulence

1. Why does the power requirement for a bioreactor increase when flooding ( when the cavities in the bioreactor hae merge together and beome large) occurs to the bioreactor? Shouldn't it have a lower power requirement since the agitators are practically spinning air and air much is less dense than liquid.

2. Why is tip speed of the agitator related to having the highest shear force in a bioreactor?
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#2
(02-08-2016, 09:01 AM)alo123 Wrote: Hi If anyone can help me answer the following questions below, it would be a great help. Its about bioreactors, turbulence

1. Why does the power requirement for a bioreactor increase when flooding ( when the cavities in the bioreactor hae merge together and beome large) occurs to the bioreactor? Shouldn't it have a lower power requirement since the agitators are practically spinning air and air much is less dense than liquid.

2. Why is tip speed of the agitator related to having the highest shear force in a bioreactor?


2) as the tip is located at a distance from the centre/axis it has a greater moment of force hence more shearing force.(just like opening a door from its edge and from another point closer to the hinges).
Tip speed is highest at the tip because the tip completes the largest circle compared to any other point on the agitator in the same time ,hence it has more speed.
Hope you got your answer:-)
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