07-18-2012, 10:32 AM
(03-26-2012, 08:46 PM)Pushing Wrote: Hello
I'v been reading a few papers about the (relatively) newly discovered phylum Acidobacterium. From what iv read it seems like any organism from this phylum would be a safe bet for antibiotic production. Large genome, soil dwelling organism, production of PKS. In spite of its being hard to culture. Yet i can’t find any papers on subjects. Im tempted to have a go my self.
I couldn't agree more!
We have a collection of Acidobacteria cultures, some of which are published (http://aem.asm.org/content/early/2011/09...1.abstract) and are working on characterizing secondary metabolites they produce. We are also working toward expressing soil metagenomic libraries (and specific large-insert clones that have PKS pathways) within an Acidobacteria host. If you're interested in learning more or helping on this project please let me know.
best regards,
Mark Liles (lilesma@auburn.edu)