Selection Guide for Monoclonal vs. Polyclonal Antibodies
The biggest difference between polyclonal and monoclonal antibodies is that polyclonal antibodies recognize multiple epitopes and monoclonal antibodies are specific to a single epitope. This primary difference impacts various features of these antibody types which need to be considered to identify the best choice for your applications including:
1.Epitope specificity
2.Volume needed
3.Continuity of supply
4.Tolerance to changes to the antigen
5.Cross-reactivity
6.Use across related species
7.Turnaround time
8.Cost
The biggest difference between polyclonal and monoclonal antibodies is that polyclonal antibodies recognize multiple epitopes and monoclonal antibodies are specific to a single epitope. This primary difference impacts various features of these antibody types which need to be considered to identify the best choice for your applications including:
1.Epitope specificity
2.Volume needed
3.Continuity of supply
4.Tolerance to changes to the antigen
5.Cross-reactivity
6.Use across related species
7.Turnaround time
8.Cost
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