09-18-2013, 11:14 PM
Ethnicity and lipoprotein diameter profile
Other associations of disease resistance with ethnicity have been recently highlighted in the literature, specifically related to insulin resistance and cardiovascular disease. A group in Birmingham, Alabama looked at mean lipoprotein particle diameters. Differences in the distribution of diameters of lipoproteins such as VLDL and HDL are associated with susceptibility to diseases including insulin resistance and cardiovascular disease. Lipoprotein sizes are associated with disease risk, but the profile of lipoproteins can be influenced by diet and exercise. Thus these present an attractive target for clinical interventions.
This study examined genetic differences which could impact on mean lipoprotein particle diameters between Caucasian, African-American, Chinese and Hispanic ethnic groups. They first assessed genotypes from Caucasian participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) and looked for association with fasting mean particle diameters. They then checked the Caucasian population of the Multi-Ethnic Study of Atherosclerosis (MESA) to determine if the associations observed were replicated before extending the analysis to the African-American, Chinese and Hispanic MESA populations.
The study found that two gene/lipoprotein density associations were notable. Firstly, variants in the apolipoprotein B (APOB) gene region, which encodes the primary apolipoproteins of chylomicrons and low-density lipoproteins (LDL), were significantly associated with mean VLDL diameter in the Caucasians both in GOLDN and MESA and with the Hispanic populations of MESA. Variation in the hepatic lipase (LIPC) gene, which encodes the enzyme that converts intermediate-density lipoprotein (IDL) to LDL, was associated with mean HDL diameter only in the Caucasians populations. Thus the findings seem to support ethnic variations in the genes directing at mean lipoprotein particle diameters, which have implications for ethnic-specific interventions in modification of lipoprotein profiles to target insulin resistance and cardiovascular disease.
Source
FRAZIER-WOOD, A. et al., 2013. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Human Genetics, 132(4), pp. 405-413
Other associations of disease resistance with ethnicity have been recently highlighted in the literature, specifically related to insulin resistance and cardiovascular disease. A group in Birmingham, Alabama looked at mean lipoprotein particle diameters. Differences in the distribution of diameters of lipoproteins such as VLDL and HDL are associated with susceptibility to diseases including insulin resistance and cardiovascular disease. Lipoprotein sizes are associated with disease risk, but the profile of lipoproteins can be influenced by diet and exercise. Thus these present an attractive target for clinical interventions.
This study examined genetic differences which could impact on mean lipoprotein particle diameters between Caucasian, African-American, Chinese and Hispanic ethnic groups. They first assessed genotypes from Caucasian participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) and looked for association with fasting mean particle diameters. They then checked the Caucasian population of the Multi-Ethnic Study of Atherosclerosis (MESA) to determine if the associations observed were replicated before extending the analysis to the African-American, Chinese and Hispanic MESA populations.
The study found that two gene/lipoprotein density associations were notable. Firstly, variants in the apolipoprotein B (APOB) gene region, which encodes the primary apolipoproteins of chylomicrons and low-density lipoproteins (LDL), were significantly associated with mean VLDL diameter in the Caucasians both in GOLDN and MESA and with the Hispanic populations of MESA. Variation in the hepatic lipase (LIPC) gene, which encodes the enzyme that converts intermediate-density lipoprotein (IDL) to LDL, was associated with mean HDL diameter only in the Caucasians populations. Thus the findings seem to support ethnic variations in the genes directing at mean lipoprotein particle diameters, which have implications for ethnic-specific interventions in modification of lipoprotein profiles to target insulin resistance and cardiovascular disease.
Source
FRAZIER-WOOD, A. et al., 2013. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Human Genetics, 132(4), pp. 405-413
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