[SunilNagpal]

hi friends,
   I'm pursuing doctrate which has drug designing part. I know somewhat but not good enough to carry out this part. pls help me by suggesting some books , websites, tutorials for knowing the basics and practical bioinformatics to know about protein structure retrieval,  protein information retrieval, docking etc..

pls help me friends. thank you for all

Hi,

Autodock has quite an exhaustive manual with crisp description of active-site - ligand docking/interaction. There are ample video tutorials for the same on youtube as well (believe me, they are among-st the best and most easily comprehendable). You may try Autodock vina too (minimal need for user interference). But I would suggest going for Autodock, than Vina.

Best book to follow for Molecular Modeling and learning basic and advanced concepts for drug designing would be Andrew Leach's [b]Molecular Modelling: Principles and Applications.[/b]

I strongly suggest against the use of multiple books and tools (you will end up confusing yourself).

For protein structure and information retrieval, digging deep into PDB is the best shot.

Following info from PDB will be of use (taken as it is from the website):

• SF-Tool [pdf]
  
  
• pdb_extract [pdf]
  
  
• RCSB PDB Mobile [pdf]
  
  
• MyPDB [pdf]
  
  
• Ligand Explorer [pdf]
  
  
• Molecules in Motion Kiosk Viewer [pdf]
  
  
• Comparison Tool [pdf]
  
  
• Widgets Information [pdf]
  
  
• Birch Aquarium Exhibit [pdf]
  
  
• Educational Resources Highlights [pdf]
  
  
• General Information [pdf]
  
  
• ImmersivePDB [pdf]
  
  
• Molecule of the Month 2006 Highlights [pdf]
  
  
• Structure Deposition: 5 Easy Steps [pdf]
  
  
• Ligand Searching [pdf]
  

Best wishes