[Samidha]

Nuclease s1 will digest only ssDNA and ssRNA.. if we consider in forensic science, during DNA fingerprinting we may use it to digest ssDNA overhangs so that when we run the sample through gel in electrophoresis... no complication will arise. .

S1 mapping of an intron site. Nuclease digest the unhybridized intronic DNA which is not present in RNA.