01-05-2014, 11:01 AM
Gene Therapy
Human DNA is supposed to have about twelve million SNPS generally known as single nucleotidepolymorphisms apart from copy number variants in thousands. Yes, most of them are harmful and serious for human survival. It is the reason that genetic disorder happens to result in mutations that changes protein functionality. Gene therapy has a prime focus on ameliorating the defected or mutated genes through the following techniques:
1. Normal gene is instilled into the genome
2. Replacement of affected gene with normal
3. Amelioration of affected gene
4. Change in regulation of certain gene
The result of therapeutic treatment has been marginal. This style of ameliorating the gene is qualitative particularly dealing with single-gene disorder. Besides, the investigation in this matter is still under going.
Ethics of Gene Therapy
Conception of altering Dna of someone for curing a serious gene diseases has been completely changed from old styles of remedies. Yes, physical therapy, pharmaceuticals and surgery are totally different practices when it comes to execute gene therapy. It is the reason that most of the people are afraid of the therapy.
Most of the defects have been notified as enzyme defects. Not only this, there are other disorders like (DMD) Duchenne muscular dystrophy of which the outcome is absolute failure of protein functions. This disease is occurred owing to mutation process in dystrophin gene. This mutation fails regeneration of muscles which results in absolute muscle weaknesses. Presently, there is no treatment available to deal with this serious (DMD) diseases. Although, for individuals the one of the method cited above may help in recurring to peaceful life.
Inspite of this serious disease, most of the people raise their voice against the therapy. They display religious grounds against this therapy and hold the opinion that it is totally against the divine law as well as God (The Creator).
Human DNA is supposed to have about twelve million SNPS generally known as single nucleotidepolymorphisms apart from copy number variants in thousands. Yes, most of them are harmful and serious for human survival. It is the reason that genetic disorder happens to result in mutations that changes protein functionality. Gene therapy has a prime focus on ameliorating the defected or mutated genes through the following techniques:
1. Normal gene is instilled into the genome
2. Replacement of affected gene with normal
3. Amelioration of affected gene
4. Change in regulation of certain gene
The result of therapeutic treatment has been marginal. This style of ameliorating the gene is qualitative particularly dealing with single-gene disorder. Besides, the investigation in this matter is still under going.
Ethics of Gene Therapy
Conception of altering Dna of someone for curing a serious gene diseases has been completely changed from old styles of remedies. Yes, physical therapy, pharmaceuticals and surgery are totally different practices when it comes to execute gene therapy. It is the reason that most of the people are afraid of the therapy.
Most of the defects have been notified as enzyme defects. Not only this, there are other disorders like (DMD) Duchenne muscular dystrophy of which the outcome is absolute failure of protein functions. This disease is occurred owing to mutation process in dystrophin gene. This mutation fails regeneration of muscles which results in absolute muscle weaknesses. Presently, there is no treatment available to deal with this serious (DMD) diseases. Although, for individuals the one of the method cited above may help in recurring to peaceful life.
Inspite of this serious disease, most of the people raise their voice against the therapy. They display religious grounds against this therapy and hold the opinion that it is totally against the divine law as well as God (The Creator).
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