09-30-2017, 02:20 PM
09-30-2017, 03:35 PM
(09-30-2017, 02:20 PM)Fazlil Wrote: [ -> ]Why Proline doesn't favour formation of alpha helix?
The 5 - membered ring of proline prevents rotation about alpha C - N bond and proline introduces a destabilizing kink in the alpha helix. In addition proline residue linked by an amide bond doesn't have a hydrogen atom to form hydrogen bonds with other residues. Therefore, Proline is also Known as Helix breaker.